*所属院系： 新浦京8883官网登录页面应用化学系

*个人简述：杨冬燕，汉族，2012年6月毕业于中国农业大学理学院化学系，获理学学士学位；并保送本校研究生，理学院化学系农药学专业硕博连读，导师：覃兆海教授，2017年6月毕业，获理学博士学位。2017年7月，在南开大学化学学院从事博士后研究工作，导师：李正名院士。

*主要研究方向： （1）植物免疫调控杀菌剂的设计合成及生物活性研究（2）绿色农用化学品的设计与开发工作。

近五年来主持和参与的主要科研项目：

(1) 国家自然科学基金项目，32302420，基于诱导系统抗性的多取代吡唑衍生物的合成及其生物活性评价，2024/01-2026/12，30万元，在研，主持；

(2) 广东省基础与应用基础研究基金青年基金，2020A1515111112，多取代吡唑衍生物的合成及其抑菌活性研究，2020/10-2023/09，10万元，结题，主持；

(3) 广州市基础与应用基础研究基金，202102020214，苯并噁嗪酮衍生物的合成及其抑菌活性研究，2021/04-2023/03月31日，5万元，结题，主持。

(4) 国家自然科学基金项目“ 选择性ABA类似物的创制及作为脱落酸受体功能化学探针的研究”(批准号：21572265), 2016年1月-2019年12月，参与。

(5) 国家自然科学基金项目“ 天然源稠三环螺内酯的抗植物病毒作用机制及其先导优化”(批准号：31872007), 2019年1月-2022年12月，参与。

主要论文：

1. Bin Yu, Bin Zhao, Zesheng Hao, Lei Chen, Lixin Cao, Xiaofeng Guo*, Nailou Zhang, Dongyan Yang*, Liangfu Tang, Zhijin Fan*. Design, synthesis and biological evaluation of pyrazole-aromatic containing carboxamides as potent SDH inhibitors. Eur J Med Chem, 2021,214, 113230.

2. Dongyan Yang, Haixia Wang, Zhijin Fan*, Zhengming Li*, Shuang Zhou, Zesheng Hao, You Lv, Tatiana A. Kalinina, Tatiana V. Glukhareva*. Design, synthesis and antifungal activity of (E)-3-acyl-5-(methoxyimino)-1,5-dihydrobenzo[e][1,2]oxazepin-4(3H)-one analogues. Mol divers,2021, 25:159–169.

3. Nailou Zhang, Shuang Zhou, Dongyan Yang*, Zhijin Fan*. Revealing Shared and Distinct Genes Responding to JA and SA Signaling in Arabidopsis by Meta-Analysis. Front. Plant Sci. 2020, 11, 113230.

4. Dongyan Yang, Bin Zhao, Zhijin Fan*, Bin Yu, Nailou Zhang, Zhengming Li*, Yilin Zhu, Jinghui Zhou, Tatiana A. Kalinina, Tatiana V. Glukhareva. Synthesis and biological activity of novel succinate dehydrogenase inhibitor derivatives as potent fungicide candidates. J. Agric. Food Chem. 2019, 67(47): 13185-13194.

5. Bin Zhao, Haixia Wang, Zhijin Fan*, Qifan Wu, Xiaofeng Guo, Nailou Zhang, Dongyan Yang,* Bin Yu, Shuang Zhou. Mode of action for a new potential fungicide candidate,3-(4-Methyl-1,2,3-thiadiazolyl)-6-trichloromethyl-[1,2,4]-triazolo-[3,4-b][1,3,4]-thiadiazole by iTRAQ. Food Agr. Immunol. 2019, 30, 1, 533-547.

6. Xiaofeng Guo, Dongyan Yang*, Zhijin Fan*, Nailou Zhang, Bin Zhao, Chun Huang, Fangjie Wang, Rongji Ma, Meng Meng*, and Youcai Deng*, Discovery and structure-activity relationship of novel diphenylthiazole derivatives as BTK inhibitor with potent activity against B cell lymphoma cell lines. Eur. J. Med. Chem. 2019, 178, 767-781.

7. Bin Zhao, Sijia Fan, Zhijin Fan*, Haixia Wang, Nailou Zhang, Xiaofeng Guo, Dongyan Yang*, Qi Fan Wu, Bin Yu, Shuang Zhou. Discovery of pyruvate kinase as a novel target of new fungicide candidate 3-(4-methyl-1,2,3-thiadiazolyl)-6-trichloromethyl-[1,2,4]-triazolo-[3,4-b][1,3,4]- thiadiazole. J. Agric. Food Chem., 2018, 66(28): 12439-12452.

8. Qifan Wu, Bin Zhao, Zhijin Fan*, Jiabao Zhao, Xiaofeng Guo, Dongyan Yang,* Nailou Zhang, Bin Yu, Tatiana Kalinina* and Tatiana Glukhareva. Design, synthesis and fungicidal activity of isothiazole-thiazole derivatives. RSC Adv., 2018, 8(69): 39593-39601.

9. Dongyan Yang, Chuan Wan, Yumei Xiao, Chuanliang Che, Changhui Rui, Zhaohai Qin*. Design, synthesis, and insecticidal activity of novel 1-alkoxy-2-nitroguanidines. RSC adv. 2018,8,1838-1845.

10. Dongyan Yang, Chuan Wan, Mengmeng He, Chuanliang Che, Yumei Xiao, Bin Fu, Zhaohai Qin*. Design, synthesis, crystal structure and fungicidal activity of (E)-5-(methoxyimino)-3,5-dihydrobenzo[e][1,2]oxazepin-4(1H)-one analogues. MedChemComm. 2017, 8, 1007-1014.

11. Yong Xu#, Dongyan Yang#, Xianggao Zou, Changhui Rui, ZiyuanZhou, Yongqiang Ma, Zhaohai Qin*. Design, synthesis and insecticidal activity of novel hydrocarbylidene nitrohydrazinecarboximidamides. Pest Manag Sci. 2017, 73, 1927-1934. (Equally contributed as first author)

12. Dongyan Yang, Lei Wang, Changqing Jia, Changsheng Li, Yongqiang Ma*, Changhui Rui, Yanjun Xu, Zhaohai Qin*. Syntheses and insecticidal activities of nitro arylideneamino guanidine derivatives. Chem J Chinese U, 2014, 35(8):1703-1709

13. Xuelian Liu#, Dongyan Yang#, Fahong Yin, Jia-Qi Li, Yumei Xiao, Bin Fu, Zhaohai Qin. The application of “plug-in molecules” method in novel strobilurin fungicides screening. RSC Adv., 2020, 10, 42804–42809 (Equally contributed as first author)

14. 杜士杰#, 杨冬燕#, 万川, 赵峰海, 覃兆海.新型芳氧吡啶肟醚类化合物的设计、合成和杀虫活性农药学学报，2021, 23(3): 476-482

15. Dongyan Yang, Xin Qi, Tatiana A. Kalinina, Tatiana V. Glukhareva, Nailou Zhang, Zesheng Hao, Zhengming Li*, Zhijin Fan*. Synthesis of 1,2,3-Thiadiazole- and Isothiazole-Based Phenyl Substituted Pyridine Containing Carboxyamide as Potent Plant Elicitors. Pest Manag Sci. 2022; 78: 1138–1145

16. Chuan Wan #, Dongyan Yang#, Ruiyuan Liu, Huizhe Lu*, Chuanliang Che, Yanjun Xu, Xueqin Zhang, Yumei Xiao, Jia-Qi Li, Zhaohai Qin*. 1’-OH of ABA and its analogs is a crucial functional group correspondence to seed germination and development of plants. Journal of Molecular Structure, (2022) 1249,131650.

17. Dongyan Yang, Xin Qi, Xinhua Zhou, Zhengming Li, Hongjun Zhou* and Zhijin Fan*. Synthesis of Potent Antifungal 3,4-Dichloroisothiazole-Based Strobilurins with Both Direct Fungicidal Activity and Systemic Acquired Resistance. 2022, RSC Med. Chem., 2022,13, 429-435.

18. Rui Wang#, Dongyan Yang#, Tian Tian, Yuhao An, Chuan Wan, Qi Chang, Mingchan Liang, Zhanfeng Hou, Ying Wang, Liang Zhang*, Zigang Li*. Low-toxicity Sulfonium-based Probes for Cysteine-specific Profiling in Live Cells. Analytical Chemistry. Anal. Chem. 2022, 94, 4366−4372.

19. Chuan Wan#, Dongyan Yang#, Xuan Qin, Ziyi Xue, Xiaochun Guo, Zhanfeng Hou, Chenran

Jiang, Feng Yin*, Rui Wang*, Zigang Li*. Flavin catalyzed desulfurization of peptide and protein in aqueous media. Org. Biomol. Chem., 2022, 20,4105-4109.

20. 杨冬燕，周新华，周红军. 基于项目驱动的硕本联动科研创新能力培养,广州化工, 2022.Vol. 50 No. 13, 27-29.

21. Liu Min#, Yang Dongyan#, Xiao Yumei*, Su Wangcang, Zhao Fenghai, Qin Zhaohai*.Synthesis and Bioactivities of 5-Nitroimino-[1,4-2H]-1,2,4-triazolines as Olefin-imidacloprid Mimics. Chin. J. Org. Chem. 2023, 43 (8): 2790-2799

22. Chuan Wan#, Zhanfeng Hou#,Dongyan Yang#, Ziyuan Zhou, Hongkun Xu, Yuena Wang, Chuan Dai, Mingchan Liang, Jun Meng, Jiean Chen, Feng Yin*, Rui Wang*, Zigang Li*. The thiol-sulfoxonium ylide photo-click reaction for bioconjugation. Chemical Science, 2023, 14, 604-612.

联系方式：何鸿燊实验楼A座213室

yangdongyan@zhku.edu.cn